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KMID : 0921620220520010028
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Journal of Bacteriology and Virology
2022 Volume.52 No. 1 p.28 ~ p.38
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Genetic Distribution of Carbapenem-Resistant Enterobacteriaceae in Seoul Korea, 2018~2020
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Park Sang-Hun
Park So-Hyun
Kim Jin-Seok
Yu Jin-Kyung
Kim Jin-Kyoung
Suh Hyo-Sun
Kwon Eun-Young
Park Kyoung-Ae
Cha Eui-Kyung
Shin Jae-Min
Jeoung Hyo-Won
Jeon Su-Jin
Hwang Young-Ok
Lee Jib-Ho
Shin Yong-Seoung
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Abstract
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The present study was carried out to describe the prevalence and characteristics of CPEs among the CRE strains isolated from adult and children patients. A total of 8,147 clinical isolates were obtained from blood, urine, stool, sputum, lesion, bile, pus, tracheal aspiration, and etc., hospitals from 2018 to 2020. Species identification was confirmed by Bruker Biotyper MALDI-TOF MS (Bruker Daltonics GmbH, Bremen, Germany) and VITEK 2 (bioMerieux, Marcy l'Etoile, France). K. pneumoniae, which was detected in 4,690 (58.9%), was the most common isolated CRE, followed by Escherichia coli (E. coli) (detected in 1,747 [20.8%]), Enterobacter cloacae complex (502 [6.0%]), Citrobacter koseri (265 [3.1%]), Klebsiella aerogenes (254 [3.0%]), and Citrobacter freundii (220 [2.6%]). More than half of the detected CPE types were KPC-2 (58.6%), followed by NDM-1 (7.4%), NDM-5 (3.4%). Co-existence of NDM-5 and OXA-181 was detected in E. coli (60/63, 95.2%) followed by K. pneumoniae (3/63, 4.8%). These findings provide good basic data for comprehensive surveillance of CREs suggesting that KPC Klebsiella pneumoniae carbapenemases (Klebsiella pneumoniae carbapenemases) and NDM (New Delhi metallo-β-lactamase) are widespread in Seoul, Korea.
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KEYWORD
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Carbapenem-resistant enterobacteriaceae (CRE), Carbapenemase-producing enterobacteriaceae (CPE), Klebsiella pneumoniae
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